1.1M XNAS Volume
XNAS 14 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 115,000 | 115,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 180,000 | 837,851 (1%) | 0% | 0 | Common Stock | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 195,000 | 1,032,851 (2%) | 0% | 0 | Common Stock | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 800,000 | 800,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 390,000 | 390,000 | - | - | Stock Option (Right to Buy) | |
| Christopher W. Ogden | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 115,000 | 115,000 | - | - | Stock Option (Right to Buy) | |
| Christopher W. Ogden | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 44,000 | 152,077 (0%) | 0% | 0 | Common Stock | |
| Christopher W. Ogden | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 57,500 | 209,577 (0%) | 0% | 0 | Common Stock | |
| Christopher W. Ogden | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 225,000 | 225,000 | - | - | Stock Option (Right to Buy) | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 30,000 | 205,648 (0%) | 0% | 0 | Common Stock | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 57,500 | 263,148 (0%) | 0% | 0 | Common Stock | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 140,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 115,000 | 115,000 | - | - | Stock Option (Right to Buy) | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 35,000 | 210,648 (0%) | 0% | 0 | Common Stock | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 57,500 | 268,148 (0%) | 0% | 0 | Common Stock | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey B. Landau | Chief Business Officer | 20 Aug 2024 | 11,250 | 123,237 (0%) | 0% | 0 | Common Stock | ||
| Marcia Belvin | SVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 11,250 | 0 | - | - | Performance Stock Units (PSUs) | |
| Marcia Belvin | SVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 1.23 per share. | 20 Aug 2024 | 4,181 | 175,648 (0%) | 0% | 1.2 | 5,139 | Common Stock |
| Marcia Belvin | SVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 11,250 | 179,829 (0%) | 0% | 0 | Common Stock | |
| Jeffrey B. Landau | Chief Business Officer | 20 Aug 2024 | 4,181 | 119,056 (0%) | 0% | 1.2 | 5,139 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Sale of securities on an exchange or to another person at price $ 1.23 per share. | 20 Aug 2024 | 4,181 | 130,797 (0%) | 0% | 1.2 | 5,139 | Common Stock |
| Lloyd A. Rowland | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 11,250 | 134,978 (0%) | 0% | 0 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 11,250 | 0 | - | - | Performance Stock Units (PSUs) | |
| Sean A. McCarthy | Director, CEO | Sale of securities on an exchange or to another person at price $ 1.23 per share. | 20 Aug 2024 | 13,898 | 657,851 (1%) | 0% | 1.2 | 17,082 | Common Stock |
| Sean A. McCarthy | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 37,500 | 671,749 (1%) | 0% | 0 | Common Stock | |
| Sean A. McCarthy | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 37,500 | 0 | - | - | Performance Stock Units (PSUs) | |
| Christopher W. Ogden | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.23 per share. | 20 Aug 2024 | 1,984 | 108,077 (0%) | 0% | 1.2 | 2,439 | Common Stock |
| Christopher W. Ogden | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 6,875 | 110,061 (0%) | 0% | 0 | Common Stock | |
| Christopher W. Ogden | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 6,875 | 0 | - | - | Performance Stock Units (PSUs) | |
| Jeffrey B. Landau | Chief Business Officer | 20 Aug 2024 | 11,250 | 0 | - | - | Performance Stock Units (PSUs) | ||
| Christopher W. Ogden | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 17,500 | 103,186 (0%) | 0% | 0 | Common Stock | |
| Christopher W. Ogden | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Alan Ashworth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 38,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| Mani Mohindru | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 38,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 38,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| Halley E. Gilbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 38,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 38,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 38,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| Sean McCarthy A. | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 26 Mar 2024 | 109,768 | 634,249 (1%) | 0% | 1.6 | 172,874 | Common Stock |
| McCarthy Sean A. | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Mar 2024 | 109,768 | 0 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Sale of securities on an exchange or to another person at price $ 2.09 per share. | 19 Mar 2024 | 5,268 | 117,728 (0%) | 0% | 2.1 | 10,986 | Common Stock |
| Sean A. McCarthy | Director, CEO | Sale of securities on an exchange or to another person at price $ 2.09 per share. | 19 Mar 2024 | 20,223 | 524,481 (1%) | 0% | 2.1 | 42,175 | Common Stock |
| Christopher W. Ogden | SVP, Finance and Accounting | Sale of securities on an exchange or to another person at price $ 2.09 per share. | 19 Mar 2024 | 2,971 | 85,686 (0%) | 0% | 2.1 | 6,196 | Common Stock |
| Jeffrey B. Landau | Chief Business Officer | 19 Mar 2024 | 6,562 | 110,060 (0%) | 0% | 2.1 | 13,685 | Common Stock | |
| Marcia Belvin | SVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 2.09 per share. | 19 Mar 2024 | 12,795 | 168,579 (0%) | 0% | 2.1 | 26,684 | Common Stock |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 25,000 | 122,996 (0%) | 0% | 0 | Common Stock | |
| Belvin Marcia | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | |
| W. Christopher Ogden | SVP, Finance and Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 40,000 | 88,657 (0%) | 0% | 0 | Common Stock | |
| Christopher Ogden W. | SVP, Finance and Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 154,000 | 154,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 90,000 | 544,704 (1%) | 0% | 0 | Common Stock | |
| Christopher W. Ogden | SVP, Finance and Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | |
| A. Rowland Lloyd | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | |
| Jeffrey B. Landau | Chief Business Officer | 18 Jan 2024 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | ||
| B. Jeffrey Landau | Chief Business Officer | 18 Jan 2024 | 30,000 | 116,622 (0%) | 0% | 0 | Common Stock | ||
| Sean McCarthy A. | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 420,000 | 420,000 | - | - | Stock Option (Right to Buy) | |
| Landau B. Jeffrey | Chief Business Officer | 18 Jan 2024 | 140,000 | 140,000 | - | - | Stock Option (Right to Buy) | ||
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 122,500 | 122,500 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 260,000 | 260,000 | - | - | Performance Stock Units (PSUs) | |
| Lloyd Rowland A. | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Belvin Marcia | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2024 | 26,250 | 181,374 (0%) | 0% | 0 | Common Stock | |
| A. Sean McCarthy | Director, CEO | Sale of securities on an exchange or to another person at price $ 1.38 per share. | 20 Dec 2023 | 13,551 | 454,704 (0%) | 0% | 1.4 | 18,710 | Common Stock |
| Ogden W. Christopher | SVP, Finance and Accounting | Sale of securities on an exchange or to another person at price $ 1.38 per share. | 20 Dec 2023 | 1,990 | 48,657 (0%) | 0% | 1.4 | 2,747 | Common Stock |
| Marcia Belvin | SVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 1.38 per share. | 20 Dec 2023 | 4,077 | 155,124 (0%) | 0% | 1.4 | 5,628 | Common Stock |
| Lloyd A. Rowland | General Counsel | Sale of securities on an exchange or to another person at price $ 1.38 per share. | 20 Dec 2023 | 4,077 | 97,996 (0%) | 0% | 1.4 | 5,629 | Common Stock |
| B. Jeffrey Landau | Chief Business Officer | 20 Dec 2023 | 4,077 | 86,622 (0%) | 0% | 1.4 | 5,628 | Common Stock | |
| Jeffrey B. Landau | Chief Business Officer | 17 Dec 2023 | 11,250 | 11,250 | - | - | Performance Stock Units (PSUs) | ||
| Belvin Marcia | SVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 11,250 | 159,201 (0%) | 0% | 0 | Common Stock | |
| Rowland Lloyd A. | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 11,250 | 11,250 | - | - | Performance Stock Units (PSUs) | |
| B. Jeffrey Landau | Chief Business Officer | 17 Dec 2023 | 11,250 | 90,699 (0%) | 0% | 0 | Common Stock | ||
| Sean McCarthy A. | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 37,500 | 468,255 (1%) | 0% | 0 | Common Stock | |
| W. Christopher Ogden | SVP, Finance and Accounting | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 6,875 | 6,875 | - | - | Performance Stock Units (PSUs) | |
| A. Sean McCarthy | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 37,500 | 37,500 | - | - | Performance Stock Units (PSUs) | |
| A. Rowland Lloyd | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 11,250 | 102,073 (0%) | 0% | 0 | Common Stock | |
| W. Christopher Ogden | SVP, Finance and Accounting | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 6,875 | 50,647 (0%) | 0% | 0 | Common Stock | |
| Belvin Marcia | SVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2023 | 11,250 | 11,250 | - | - | Performance Stock Units (PSUs) | |
| Landau Jeffrey B. | Chief Business Officer | 20 Sep 2023 | 11,250 | 80,498 (0%) | 0% | 0 | Common Stock | ||
| A. McCarthy Sean | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Sep 2023 | 40,000 | 445,356 (0%) | 0% | 0 | Common Stock | |
| Rowland A. Lloyd | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Sep 2023 | 15,000 | 86,095 (0%) | 0% | 0 | Common Stock | |
| Lloyd Rowland A. | General Counsel | Sale of securities on an exchange or to another person at price $ 1.30 per share. | 20 Sep 2023 | 5,486 | 80,609 (0%) | 0% | 1.3 | 7,135 | Common Stock |
| B. Jeffrey Landau | Chief Business Officer | 20 Sep 2023 | 4,119 | 76,379 (0%) | 0% | 1.3 | 5,356 | Common Stock | |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Sep 2023 | 11,250 | 152,070 (0%) | 0% | 0 | Common Stock | |
| McCarthy Sean A. | Director, CEO | Sale of securities on an exchange or to another person at price $ 1.30 per share. | 20 Sep 2023 | 14,601 | 430,755 (0%) | 0% | 1.3 | 18,987 | Common Stock |
| Belvin Marcia | SVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 1.30 per share. | 20 Sep 2023 | 4,119 | 147,951 (0%) | 0% | 1.3 | 5,356 | Common Stock |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Halley E. Gilbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Mani Mohindru | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Alan Ashworth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 19 May 2023 | 16,535 | 405,356 (0%) | 0% | 1.6 | 26,041 | Common Stock |
| Sean A. McCarthy | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2023 | 16,535 | 119,536 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Purchase of securities on an exchange or from another person at price $ 1.55 per share. | 29 Mar 2023 | 5,000 | 5,142 (0%) | 0% | 1.6 | 7,750 | Common Stock |
| Marcia Belvin | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2023 | 60,000 | 140,820 (0%) | 0% | 0 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Sale of securities on an exchange or to another person at price $ 1.98 per share. | 16 Mar 2023 | 2,037 | 71,095 (0%) | 0% | 2.0 | 4,031 | Common Stock |
| Sean A. McCarthy | Director, CEO | Sale of securities on an exchange or to another person at price $ 1.88 per share. | 16 Mar 2023 | 7,121 | 388,821 (0%) | 0% | 1.9 | 13,391 | Common Stock |
| Amy C. Peterson | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 1.98 per share. | 16 Mar 2023 | 4,257 | 58,433 (0%) | 0% | 2.0 | 8,425 | Common Stock |
| Carlos E. Campoy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.98 per share. | 16 Mar 2023 | 1,748 | 38,224 (0%) | 0% | 2.0 | 3,459 | Common Stock |
| Christopher W. Ogden | SVP, Finance and Accounting | Sale of securities on an exchange or to another person at price $ 1.98 per share. | 16 Mar 2023 | 516 | 37,772 (0%) | 0% | 2.0 | 1,021 | Common Stock |
| Jeffrey B. Landau | Chief Financial Officer | 16 Mar 2023 | 1,477 | 69,248 (0%) | 0% | 2.0 | 2,923 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 25,000 | 73,132 (0%) | 0% | 0 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 105,000 | 395,942 (0%) | 0% | 0 | Common Stock | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 315,000 | 315,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 300,000 | 300,000 | - | - | Performance Stock Units (PSUs) | |
| Christopher W. Ogden | SVP, Finance and Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 25,000 | 38,288 (0%) | 0% | 0 | Common Stock | |
| Christopher W. Ogden | SVP, Finance and Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Christopher W. Ogden | SVP, Finance and Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | |
| Jeffrey B. Landau | Chief Business Officer | 02 Feb 2023 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | ||
| Jeffrey B. Landau | Chief Business Officer | 02 Feb 2023 | 75,000 | 75,000 | - | - | Performance Stock Units (PSUs) | ||
| Jeffrey B. Landau | Chief Business Officer | 02 Feb 2023 | 40,000 | 70,725 (0%) | 0% | 0 | Common Stock | ||
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jul 2022 | 15,000 | 49,291 (0%) | 0% | 0 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Sale of securities on an exchange or to another person at price $ 1.42 per share. | 19 Jul 2022 | 5,602 | 43,689 (0%) | 0% | 1.4 | 7,968 | Common Stock |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jul 2022 | 15,000 | 37,500 (0%) | 0% | 0 | Common Stock | |
| Alison L. Hannah | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.42 per share. | 19 Jul 2022 | 5,602 | 31,898 (0%) | 0% | 1.4 | 7,965 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 1.42 per share. | 19 Jul 2022 | 14,911 | 290,942 (0%) | 0% | 1.4 | 21,206 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jul 2022 | 40,000 | 305,853 (0%) | 0% | 0 | Common Stock | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jul 2022 | 20,000 | 70,153 (0%) | 0% | 0 | Common Stock | |
| Amy C. Peterson | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 1.42 per share. | 19 Jul 2022 | 7,463 | 62,690 (0%) | 0% | 1.4 | 10,612 | Common Stock |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jul 2022 | 15,000 | 43,921 (0%) | 0% | 0 | Common Stock | |
| Carlos E. Campoy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.42 per share. | 19 Jul 2022 | 3,949 | 39,972 (0%) | 0% | 1.4 | 5,617 | Common Stock |
| Jeffrey B. Landau | Chief Business Officer | 19 Jul 2022 | 4,206 | 30,725 (0%) | 0% | 1.4 | 5,982 | Common Stock | |
| Jeffrey B. Landau | Chief Business Officer | 19 Jul 2022 | 11,250 | 34,931 (0%) | 0% | 0 | Common Stock | ||
| Frederick W. Gluck | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Halley E. Gilbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Mani Mohindru | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Alan Ashworth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2022 | 66,742 | 0 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 09 May 2022 | 66,742 | 241,664 (0%) | 0% | 0.9 | 63,071 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 09 May 2022 | 24,189 | 265,853 (0%) | 0% | 0.9 | 22,859 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2022 | 24,189 | 0 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 135,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 22,500 | 34,291 (0%) | 0% | 0 | Common Stock | |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 22,500 | 22,500 (0%) | 0% | 0 | Common Stock | |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 135,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 450,000 | 450,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 75,000 | 174,922 (0%) | 0% | 0 | Common Stock | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 40,000 | 46,421 (0%) | 0% | 0 | Common Stock | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 135,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 22,500 | 28,921 (0%) | 0% | 0 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 30,000 | 30,000 | - | - | Performance Stock Units (PSUs) | |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 30,000 | 30,000 | - | - | Performance Stock Units (PSUs) | |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 80,000 | 80,000 | - | - | Performance Stock Units (PSUs) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 40,000 | 40,000 | - | - | Performance Stock Units (PSUs) | |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2021 | 30,000 | 30,000 | - | - | Performance Stock Units (PSUs) | |
| Alan Ashworth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Sep 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 11 Aug 2021 | 92,113 | 99,922 (0%) | 0% | 1.1 | 104,447 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2021 | 92,113 | 0 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Gluck | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| John A. Scarlett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Halley E. Gilbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 7.04 per share. | 16 Jun 2021 | 100,000 | 93,118 (0%) | 0% | 7.0 | 704,470 | Common Stock |
| Mani Mohindru | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.90 per share. | 14 Jun 2021 | 10 | 7,849 (0%) | 0% | 0.9 | 9 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2021 | 10 | 66,742 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2021 | 30 | 92,113 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 14 Jun 2021 | 30 | 7,839 (0%) | 0% | 1.1 | 34 | Common Stock |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 6.09 per share. | 31 May 2021 | 3,320 | 6,421 (0%) | 0% | 6.1 | 20,206 | Common Stock |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 6.09 per share. | 31 May 2021 | 3,320 | 6,421 (0%) | 0% | 6.1 | 20,206 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2021 | 100,000 | 92,143 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 7.49 per share. | 31 Mar 2021 | 100,000 | 206,894 (0%) | 0% | 7.5 | 749,470 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 31 Mar 2021 | 100,000 | 306,894 (0%) | 0% | 1.1 | 113,390 | Common Stock |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 125,000 | 125,000 | - | - | Stock Option (right to buy) | |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 175,000 | 175,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 400,000 | 400,000 | - | - | Stock Option (right to buy) | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 250,000 | 250,000 | - | - | Stock Option (right to buy) | |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Dec 2020 | 100,000 | 192,143 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 23 Dec 2020 | 100,000 | 206,894 (0%) | 0% | 1.1 | 113,390 | Common Stock |
| Mani Mohindru | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 6.39 per share. | 30 Nov 2020 | 930 | 106,894 (0%) | 0% | 6.4 | 5,945 | Common Stock |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 6.39 per share. | 30 Nov 2020 | 3,101 | 3,101 (0%) | 0% | 6.4 | 19,822 | Common Stock |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 6.39 per share. | 30 Nov 2020 | 3,101 | 3,101 (0%) | 0% | 6.4 | 19,822 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2020 | 20,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.61 per share. | 21 Sep 2020 | 20,500 | 105,964 (0%) | 0% | 6.6 | 135,601 | Common Stock |
| Frederick W. Gluck | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| John A. Scarlett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Halley E. Gilbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Charles S. Fuchs | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 5.11 per share. | 29 May 2020 | 1,158 | 85,464 (0%) | 0% | 5.1 | 5,916 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2020 | 36,000 | 292,143 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 12 May 2020 | 36,000 | 84,306 (0%) | 0% | 15 | 540,000 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 12 May 2020 | 36,000 | 120,306 (0%) | 0% | 1.1 | 40,820 | Common Stock |
| Halley E. Gilbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Carlos E. Campoy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Mar 2020 | 350,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2020 | 120,000 | 120,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2020 | 500,000 | 500,000 | - | - | Stock Option (right to buy) | |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2020 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Robin Knifsend | Principal Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2020 | 34,000 | 34,000 | - | - | Stock Option (right to buy) | |
| Alison L. Hannah | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 250,000 | 250,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 5.32 per share. | 30 Nov 2019 | 1,080 | 84,306 (0%) | 0% | 5.3 | 5,747 | Common Stock |
| Amy C. Peterson | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2019 | 400,000 | 400,000 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2019 | 4,500 | 7,809 (0%) | 0% | 0 | Common Stock | |
| Frederick W. Gluck | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2019 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2019 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| John A. Scarlett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2019 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2019 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2019 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Charles S. Fuchs | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2019 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 8.21 per share. | 31 May 2019 | 1,812 | 11,791 (0%) | 0% | 8.2 | 14,878 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 8.21 per share. | 31 May 2019 | 695 | 83,226 (0%) | 0% | 8.2 | 5,707 | Common Stock |
| Robin Knifsend | Principal Accounting Officer | Grant, award, or other acquisition of securities at price $ 8.21 per share. | 31 May 2019 | 1,812 | 2,791 (0%) | 0% | 8.2 | 14,878 | Common Stock |
| Jones V Elaine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2019 | 28,000 | 28,000 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Apr 2019 | 3,900 | 237,015 (0%) | 0% | 0 | Common Stock | |
| Lloyd A. Rowland | General Counsel | Purchase of securities on an exchange or from another person at price $ 10.33 per share. | 04 Mar 2019 | 9,000 | 9,979 (0%) | 0% | 10.3 | 92,970 | Common Stock |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2019 | 54,900 | 54,900 | - | - | Stock Option (right to buy) | |
| Rachel Humphrey | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2019 | 90,000 | 90,000 | - | - | Stock Option (right to buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2019 | 90,000 | 90,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2019 | 300,000 | 300,000 | - | - | Stock Option (right to buy) | |
| Debanjan Ray | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2019 | 90,000 | 90,000 | - | - | Stock Option (right to buy) | |
| James R. Meyers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2018 | 28,000 | 28,000 | - | - | Stock Option (right to buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.45 per share. | 12 Dec 2018 | 3,000 | 8,928 (0%) | 0% | 1.4 | 4,347 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 12 Dec 2018 | 3,000 | 5,928 (0%) | 0% | 15 | 45,000 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2018 | 3,000 | 7,220 | - | - | Stock Option (Right to Buy) | |
| Lloyd A. Rowland | General Counsel | Grant, award, or other acquisition of securities at price $ 11.73 per share. | 30 Nov 2018 | 979 | 979 (0%) | 0% | 11.7 | 11,484 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 11.73 per share. | 30 Nov 2018 | 468 | 82,531 (0%) | 0% | 11.7 | 5,490 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.01 per share. | 01 Nov 2018 | 100 | 87,333 (0%) | 0% | 15.0 | 1,501 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.01 per share. | 01 Nov 2018 | 1,156 | 82,063 (0%) | 0% | 15.0 | 17,348 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.58 per share. | 01 Nov 2018 | 1,156 | 83,219 (0%) | 0% | 1.6 | 1,821 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 01 Nov 2018 | 5,270 | 82,063 (0%) | 0% | 15 | 79,050 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 01 Nov 2018 | 5,370 | 87,433 (0%) | 0% | 1.6 | 8,457 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2018 | 1,156 | 136,071 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2018 | 5,370 | 137,227 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2018 | 3,000 | 10,220 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 01 Nov 2018 | 3,000 | 5,928 (0%) | 0% | 15 | 45,000 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.45 per share. | 01 Nov 2018 | 3,000 | 8,928 (0%) | 0% | 1.4 | 4,347 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.46 per share. | 01 Oct 2018 | 3,000 | 5,928 (0%) | 0% | 18.5 | 55,380 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.45 per share. | 01 Oct 2018 | 3,000 | 8,928 (0%) | 0% | 1.4 | 4,347 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2018 | 3,000 | 13,220 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2018 | 13,052 | 142,597 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 21.86 per share. | 04 Sep 2018 | 13,052 | 82,063 (0%) | 0% | 21.9 | 285,343 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 04 Sep 2018 | 13,052 | 95,115 (0%) | 0% | 1.6 | 20,556 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.45 per share. | 04 Sep 2018 | 3,000 | 8,928 (0%) | 0% | 1.4 | 4,347 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.39 per share. | 04 Sep 2018 | 3,000 | 5,928 (0%) | 0% | 22.4 | 67,170 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2018 | 3,000 | 16,220 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.45 per share. | 01 Aug 2018 | 290 | 8,928 (0%) | 0% | 1.4 | 420 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 01 Aug 2018 | 2,710 | 8,638 (0%) | 0% | 1.3 | 3,414 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.05 per share. | 01 Aug 2018 | 3,000 | 5,928 (0%) | 0% | 26.1 | 78,150 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2018 | 2,710 | 0 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2018 | 290 | 19,220 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.06 per share. | 05 Jul 2018 | 4,497 | 82,063 (0%) | 0% | 25.1 | 112,689 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 05 Jul 2018 | 4,497 | 86,560 (0%) | 0% | 1.6 | 7,082 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2018 | 4,497 | 155,649 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.09 per share. | 03 Jul 2018 | 2,028 | 82,063 (0%) | 0% | 25.1 | 50,880 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 03 Jul 2018 | 2,028 | 84,091 (0%) | 0% | 1.6 | 3,194 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2018 | 2,028 | 160,146 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 02 Jul 2018 | 13,052 | 95,115 (0%) | 0% | 1.6 | 20,556 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 23.42 per share. | 02 Jul 2018 | 13,052 | 82,063 (0%) | 0% | 23.4 | 305,708 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jul 2018 | 13,052 | 162,174 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 02 Jul 2018 | 3,000 | 8,928 (0%) | 0% | 1.3 | 3,780 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.56 per share. | 02 Jul 2018 | 3,000 | 5,928 (0%) | 0% | 22.6 | 67,680 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jul 2018 | 3,000 | 2,710 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Gluck | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2018 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Hoyoung Huh | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2018 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| John A. Scarlett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2018 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Matthew P. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2018 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Charles S. Fuchs | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2018 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.93 per share. | 01 Jun 2018 | 3,000 | 5,928 (0%) | 0% | 25.9 | 77,793 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 17.90 per share. | 01 Jun 2018 | 1,187 | 5,928 (0%) | 0% | 17.9 | 21,248 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 01 Jun 2018 | 3,000 | 8,928 (0%) | 0% | 1.3 | 3,780 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2018 | 3,000 | 5,710 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 17.90 per share. | 31 May 2018 | 302 | 4,945 (0%) | 0% | 17.9 | 5,406 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2018 | 19,578 | 175,226 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 01 May 2018 | 19,578 | 24,221 (0%) | 0% | 1.6 | 30,833 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 26.55 per share. | 01 May 2018 | 19,578 | 4,643 (0%) | 0% | 26.5 | 519,743 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.52 per share. | 01 May 2018 | 3,000 | 4,741 (0%) | 0% | 26.5 | 79,562 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2018 | 3,000 | 8,710 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 01 May 2018 | 3,000 | 7,741 (0%) | 0% | 1.3 | 3,780 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Apr 2018 | 3,000 | 11,710 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 02 Apr 2018 | 3,000 | 4,741 (0%) | 0% | 28.1 | 84,360 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 02 Apr 2018 | 3,000 | 7,741 (0%) | 0% | 1.3 | 3,780 | Common Stock |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 31.93 per share. | 26 Mar 2018 | 5,000 | 271,643 (0%) | 0% | 31.9 | 159,642 | Common Stock |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 02 Mar 2018 | 16,181 | 276,643 (0%) | 0% | 30.0 | 485,466 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Mar 2018 | 16,160 | 222,980 | - | - | Stock Option (Right to Buy) | |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.61 per share. | 02 Mar 2018 | 16,160 | 46,394 (0%) | 0% | 6.6 | 106,894 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 02 Mar 2018 | 16,160 | 30,234 (0%) | 0% | 30 | 484,800 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 29.43 per share. | 01 Mar 2018 | 19,578 | 4,643 (0%) | 0% | 29.4 | 576,141 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 01 Mar 2018 | 62 | 24,221 (0%) | 0% | 1.0 | 59 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 01 Mar 2018 | 9,000 | 24,159 (0%) | 0% | 1.1 | 10,205 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 01 Mar 2018 | 10,516 | 15,159 (0%) | 0% | 1.6 | 16,562 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 10,516 | 194,804 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 9,000 | 328,143 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 62 | 66,752 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 5,515 | 14,710 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 01 Mar 2018 | 13,000 | 17,741 (0%) | 0% | 1.3 | 16,379 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.40 per share. | 01 Mar 2018 | 13,000 | 4,741 (0%) | 0% | 29.4 | 382,242 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.26 per share. | 01 Mar 2018 | 5,515 | 10,256 (0%) | 0% | 1.3 | 6,948 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.06 per share. | 01 Mar 2018 | 5,515 | 4,741 (0%) | 0% | 30.1 | 165,775 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 01 Mar 2018 | 14,485 | 19,226 (0%) | 0% | 1.1 | 16,425 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.41 per share. | 01 Mar 2018 | 12,541 | 6,685 (0%) | 0% | 30.4 | 381,384 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 31.01 per share. | 01 Mar 2018 | 1,944 | 4,741 (0%) | 0% | 31.0 | 60,293 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 14,485 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 13,000 | 20,225 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 28 Feb 2018 | 3,819 | 292,824 (0%) | 0% | 30 | 114,570 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 28 Feb 2018 | 23,840 | 30,234 (0%) | 0% | 30 | 715,200 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.61 per share. | 28 Feb 2018 | 23,840 | 54,074 (0%) | 0% | 6.6 | 157,694 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2018 | 23,840 | 239,140 | - | - | Stock Option (Right to Buy) | |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.69 per share. | 01 Feb 2018 | 2,548 | 4,741 (0%) | 0% | 26.7 | 68,010 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 75,000 | 75,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 300,000 | 300,000 | - | - | Stock Option (right to buy) | |
| Debanjan Ray | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 05 Jan 2018 | 10,000 | 296,643 (0%) | 0% | 25.0 | 250,078 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2018 | 6,526 | 337,143 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 05 Jan 2018 | 6,526 | 4,643 (0%) | 0% | 25.0 | 163,215 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 05 Jan 2018 | 6,526 | 11,169 (0%) | 0% | 1.1 | 7,400 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 21.04 per share. | 02 Jan 2018 | 13,052 | 4,643 (0%) | 0% | 21.0 | 274,614 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 02 Jan 2018 | 13,052 | 17,695 (0%) | 0% | 1.1 | 14,800 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2018 | 13,052 | 343,669 | - | - | Stock Option (right to buy) | |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.11 per share. | 02 Jan 2018 | 2,500 | 7,289 (0%) | 0% | 21.1 | 52,775 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2017 | 4,500 | 154,237 (0%) | 0% | 0 | Common Stock | |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 22.29 per share. | 26 Dec 2017 | 5,000 | 306,643 (0%) | 0% | 22.3 | 111,426 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.61 per share. | 15 Dec 2017 | 15,117 | 30,234 (0%) | 0% | 6.6 | 99,994 | Common Stock |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2017 | 15,117 | 262,980 | - | - | Stock Option (Right to Buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.57 per share. | 08 Dec 2017 | 5,130 | 19,047 (0%) | 0% | 1.6 | 8,079 | Common Stock |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2017 | 5,130 | 240,912 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 12.15 per share. | 01 Dec 2017 | 398 | 4,643 (0%) | 0% | 12.1 | 4,834 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2017 | 4,100 | 115,193 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.60 per share. | 01 Dec 2017 | 14,340 | 4,643 (0%) | 0% | 20.6 | 295,404 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2017 | 10,240 | 356,721 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 01 Dec 2017 | 10,240 | 18,983 (0%) | 0% | 1.1 | 11,611 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 01 Dec 2017 | 4,100 | 8,743 (0%) | 0% | 0.9 | 3,875 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 12.15 per share. | 01 Dec 2017 | 163 | 12,289 (0%) | 0% | 12.1 | 1,980 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.58 per share. | 01 Dec 2017 | 2,500 | 9,789 (0%) | 0% | 20.6 | 51,450 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2017 | 14,342 | 119,293 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 19.86 per share. | 01 Nov 2017 | 14,342 | 4,245 (0%) | 0% | 19.9 | 284,832 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 01 Nov 2017 | 14,342 | 18,587 (0%) | 0% | 0.9 | 13,553 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 01 Nov 2017 | 2,500 | 12,126 (0%) | 0% | 20 | 50,000 | Common Stock |
| Charles S. Fuchs | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Oct 2017 | 28,000 | 28,000 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 24.27 per share. | 04 Oct 2017 | 10,000 | 311,643 (0%) | 0% | 24.3 | 242,680 | Common Stock |
| Robert Tepper | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 24.34 per share. | 04 Oct 2017 | 24,777 | 29,516 (0%) | 0% | 24.3 | 603,072 | Common Stock |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Oct 2017 | 48,368 | 48,368 | - | - | Stock Option (Right to Buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.47 per share. | 04 Oct 2017 | 48,368 | 62,285 (0%) | 0% | 4.5 | 216,340 | Common Stok |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Sale of securities on an exchange or to another person at price $ 24.34 per share. | 04 Oct 2017 | 48,368 | 13,917 (0%) | 0% | 24.3 | 1,177,277 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 24.13 per share. | 04 Oct 2017 | 19,120 | 4,245 (0%) | 0% | 24.1 | 461,366 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 04 Oct 2017 | 19,120 | 23,365 (0%) | 0% | 0.9 | 18,068 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Oct 2017 | 19,120 | 133,635 | - | - | Common Stock | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2017 | 9,562 | 15,481 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 18.57 per share. | 02 Oct 2017 | 9,562 | 4,245 (0%) | 0% | 18.6 | 177,566 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 02 Oct 2017 | 9,562 | 13,807 (0%) | 0% | 0.9 | 9,036 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.10 per share. | 02 Oct 2017 | 2,500 | 14,626 (0%) | 0% | 18.1 | 45,250 | Common Stock |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 17.30 per share. | 26 Sep 2017 | 5,000 | 321,643 (0%) | 0% | 17.3 | 86,476 | Common Stock |
| Robert Tepper | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 19 Sep 2017 | 20,000 | 54,293 (0%) | 0% | 18 | 360,000 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.32 per share. | 01 Sep 2017 | 9,562 | 4,613 (0%) | 0% | 17.3 | 165,614 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 01 Sep 2017 | 9,930 | 14,175 (0%) | 0% | 0.9 | 9,384 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2017 | 9,930 | 25,043 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 01 Sep 2017 | 368 | 4,245 (0%) | 0% | 17.5 | 6,440 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 17.17 per share. | 01 Sep 2017 | 2,500 | 17,126 (0%) | 0% | 17.2 | 42,925 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 31 Aug 2017 | 18,756 | 23,001 (0%) | 0% | 0.9 | 17,724 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 31 Aug 2017 | 6,562 | 16,439 (0%) | 0% | 17.5 | 114,835 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.51 per share. | 31 Aug 2017 | 3,000 | 13,439 (0%) | 0% | 17.5 | 52,530 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 31 Aug 2017 | 9,194 | 4,245 (0%) | 0% | 17.5 | 160,895 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2017 | 18,756 | 34,973 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2017 | 4,781 | 53,729 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 09 Aug 2017 | 4,781 | 4,245 (0%) | 0% | 15 | 71,715 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 09 Aug 2017 | 4,781 | 9,026 (0%) | 0% | 0.9 | 4,518 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 09 Aug 2017 | 2,500 | 19,626 (0%) | 0% | 15 | 37,500 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.52 per share. | 03 Jul 2017 | 4,781 | 4,245 (0%) | 0% | 15.5 | 74,201 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 03 Jul 2017 | 4,781 | 9,026 (0%) | 0% | 0.9 | 4,518 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2017 | 4,781 | 58,510 | - | - | Stock Option (right to buy) | |
| Debanjan Ray | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.47 per share. | 03 Jul 2017 | 2,500 | 22,126 (0%) | 0% | 15.5 | 38,675 | Common Stock |
| Robert Tepper | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 16.00 per share. | 29 Jun 2017 | 15,000 | 44,777 (0%) | 0% | 16 | 240,000 | Common Stock |
| Frederick W. Gluck | None | Sale of securities on an exchange or to another person at price $ 14.61 per share. | 26 Jun 2017 | 5,000 | 326,643 (0%) | 0% | 14.6 | 73,050 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 26 Jun 2017 | 4,481 | 8,726 (0%) | 0% | 0.9 | 4,235 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 26 Jun 2017 | 4,481 | 4,245 (0%) | 0% | 15 | 67,215 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2017 | 4,481 | 63,291 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Hoyoung Huh | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| John A. Scarlett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Matthew P. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Neil Exter | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Marion McCourt | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2017 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2017 | 300 | 67,772 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 05 Jun 2017 | 300 | 4,545 (0%) | 0% | 0.9 | 284 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 05 Jun 2017 | 300 | 4,245 (0%) | 0% | 15 | 4,500 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 8.68 per share. | 31 May 2017 | 2,266 | 4,245 (0%) | 0% | 8.7 | 19,665 | Common Stock |
| Debanjan Ray | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 8.68 per share. | 31 May 2017 | 2,698 | 24,626 (0%) | 0% | 8.7 | 23,415 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2017 | 9,980 | 204,678 | - | - | Stock Option (Right to Buy) | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.61 per share. | 12 May 2017 | 9,987 | 32,756 (0%) | 0% | 6.6 | 66,061 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.47 per share. | 12 May 2017 | 9,980 | 22,769 (0%) | 0% | 4.5 | 44,639 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2017 | 9,987 | 85,891 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 01 May 2017 | 4,781 | 6,760 (0%) | 0% | 0.9 | 4,518 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2017 | 4,781 | 68,072 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.70 per share. | 01 May 2017 | 4,781 | 1,979 (0%) | 0% | 15.7 | 75,062 | Common Stock |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2017 | 48,368 | 96,736 | - | - | Stock Option (Right to Buy) | |
| Kevin P. Starr | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 16.36 per share. | 12 Apr 2017 | 28,357 | 31,419 (0%) | 0% | 16.4 | 463,793 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.47 per share. | 10 Apr 2017 | 3,000 | 12,789 (0%) | 0% | 4.5 | 13,418 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2017 | 3,000 | 214,658 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 03 Apr 2017 | 4,781 | 1,979 (0%) | 0% | 17.5 | 83,668 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2017 | 4,781 | 77,634 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 03 Apr 2017 | 4,781 | 6,760 (0%) | 0% | 0.9 | 4,518 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2017 | 4,781 | 72,853 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.94 per share. | 03 Apr 2017 | 4,781 | 1,979 (0%) | 0% | 16.9 | 80,990 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 03 Apr 2017 | 4,781 | 6,760 (0%) | 0% | 0.9 | 4,518 | Common Stock |
| Marion McCourt | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2017 | 28,000 | 28,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Mar 2017 | 14,343 | 82,415 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.94 per share. | 20 Mar 2017 | 14,343 | 16,322 (0%) | 0% | 0.9 | 13,554 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 19.60 per share. | 20 Mar 2017 | 14,343 | 1,979 (0%) | 0% | 19.6 | 281,123 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 20 Mar 2017 | 11,517 | 9,789 (0%) | 0% | 20 | 230,340 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.60 per share. | 20 Mar 2017 | 10,000 | 21,306 (0%) | 0% | 19.6 | 196,000 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.47 per share. | 20 Mar 2017 | 21,517 | 31,306 (0%) | 0% | 4.5 | 96,241 | Common Stock |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Mar 2017 | 21,517 | 217,658 | - | - | Stock Option (Right to Buy) | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2017 | 2,500 | 239,175 | - | - | Stock Option (right to buy) | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.47 per share. | 09 Mar 2017 | 2,500 | 9,789 (0%) | 0% | 4.5 | 11,182 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 03 Mar 2017 | 14,343 | 16,322 (0%) | 0% | 1.1 | 16,264 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 03 Mar 2017 | 14,343 | 1,979 (0%) | 0% | 15 | 215,145 | Common Stock |
| Sean A. McCarthy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2017 | 14,343 | 366,961 | - | - | Stock Option (Right to Buy) | |
| Cynthia Ladd | Senior VP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2017 | 84,000 | 84,000 | - | - | Stock Option (right to buy) | |
| Rachel Humphrey | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2017 | 120,000 | 120,000 | - | - | Stock Option (right to buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2017 | 120,000 | 120,000 | - | - | Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2017 | 310,000 | 310,000 | - | - | Stock Option (right to buy) | |
| Robert C. Goeltz | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2017 | 84,000 | 84,000 | - | - | Stock Option (right to buy) | |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2016 | 15,117 | 278,097 | - | - | Stock Option (Right to Buy) | |
| Rachel Humphrey | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2016 | 15,117 | 15,117 | - | - | Common Stock | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 1,979 | 1,979 | - | - | Common Stock | |
| Robert C. Goeltz | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 1,289 | 7,289 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 29 Nov 2016 | 22,086 | 3,244,381 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Nov 2016 | 10,890 | 3,694,036 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Nov 2016 | 6,729 | 3,687,307 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Nov 2016 | 20,840 | 3,666,467 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 22 Nov 2016 | 42,550 | 3,704,926 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 Nov 2016 | 18,971 | 3,773,829 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 Nov 2016 | 12,805 | 3,761,024 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 Nov 2016 | 13,548 | 3,747,476 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 15 Nov 2016 | 33,064 | 3,811,317 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 15 Nov 2016 | 18,517 | 3,792,800 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Nov 2016 | 27,135 | 3,903,516 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Nov 2016 | 35,391 | 3,868,125 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Nov 2016 | 23,744 | 3,844,381 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 09 Nov 2016 | 13,730 | 3,930,651 | - | - | Common Stock | |
| Mark J. Levin | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 07 Nov 2016 | 1,000,000 | 7,670,348 | - | - | Common Stock | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2016 | 4,000 | 241,675 | - | - | Employee Stock Option (right to buy) | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2016 | 4,000 | 6,000 | - | - | Common Stock | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Sep 2016 | 48,368 | 48,368 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Sep 2016 | 48,379 | 48,379 | - | - | Stock Option (Right to Buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Sep 2016 | 122,424 | 122,424 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 31,767 | 0 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 16,612 | 0 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 27,606 | 0 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 17,139 | 0 | - | - | Stock Option (right to buy) | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 31,767 | 179,558 | - | - | Common Stock | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 16,612 | 196,170 | - | - | Common Stock | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 27,606 | 223,776 | - | - | Common Stock | |
| Frederick W. Gluck | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2016 | 17,139 | 240,915 | - | - | Common Stock | |
| Frederick W. Gluck | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2016 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Timothy M. Shannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2016 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| John A. Scarlett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2016 | 28,000 | 28,000 | - | - | Stock Option (right to buy) | |
| Hoyoung Huh | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2016 | 28,000 | 28,000 | - | - | Stock Option (right to buy) | |
| Matthew P. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2016 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Neil Exter | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2016 | 14,000 | 14,000 | - | - | Stock Option (right to buy) | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 08 Jun 2016 | 22,885 | 4,269,923 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 08 Jun 2016 | 22,842 | 4,247,081 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 08 Jun 2016 | 2,700 | 4,244,381 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 Jun 2016 | 101,767 | 4,302,539 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 Jun 2016 | 9,731 | 4,292,808 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Jun 2016 | 41,193 | 4,422,734 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Jun 2016 | 18,428 | 4,404,306 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jun 2016 | 22,463 | 4,463,927 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 27 May 2016 | 25,082 | 4,486,390 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 25 May 2016 | 11,456 | 4,551,359 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 25 May 2016 | 39,887 | 4,511,472 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 May 2016 | 12,053 | 4,564,015 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 May 2016 | 1,200 | 4,562,815 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 19 May 2016 | 2,500 | 4,582,255 | - | - | Common Stock | |
| Timothy M. Shannon | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 19 May 2016 | 6,187 | 4,576,068 | - | - | Common Stock | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2016 | 2,000 | 245,675 | - | - | Employee Stock Option (right to buy) | |
| Robert C. Goeltz | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2016 | 2,000 | 2,000 | - | - | Common Stock | |
| Frederick W. Gluck | None | Other type of transaction at price $ 0.00 per share. | 05 Apr 2016 | 331,643 | 331,643 | - | - | Common Stock | |
| Frederick W. Gluck | None | Other type of transaction at price $ 0.00 per share. | 05 Apr 2016 | 17,111 | 22,111 | - | - | Common Stock | |
| Cynthia Ladd | Senior VP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2016 | 45,000 | 45,000 | - | - | Employee Stock Option (right to buy) | |
| Rachel Humphrey | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2016 | 65,000 | 65,000 | - | - | Employee Stock Option (right to buy) | |
| W. Michael Kavanaugh | CSO, Head Res.&Non-Clin. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2016 | 80,000 | 80,000 | - | - | Employee Stock Option (right to buy) | |
| Sean A. McCarthy | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2016 | 225,000 | 225,000 | - | - | Employee Stock Option (right to buy) | |
| Robert C. Goeltz | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2016 | 80,000 | 80,000 | - | - | Employee Stock Option (right to buy) | |
| W. Michael Kavanaugh | Chief Scientific Officer and | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2015 | 8,917 | 76,688 | - | - | Employee Stock Option (right to buy) | |
| W. Michael Kavanaugh | Chief Scientific Officer and | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2015 | 8,917 | 13,917 | - | - | Common Stock | |
| Mark J. Levin | Ten Percent Owner | 14 Oct 2015 | 8,105,314 | 0 | - | - | Series B-1 Preferred Stock | ||
| Mark J. Levin | Ten Percent Owner | 14 Oct 2015 | 565,037 | 0 | - | - | Series C Preferred Stock | ||
| Mark J. Levin | Ten Percent Owner | 14 Oct 2015 | 8,670,351 | 8,670,351 | - | - | Common Stock | ||
| Frederick W. Gluck | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Oct 2015 | 10,000 | 147,791 | - | - | Common Stock | |
| Frederick W. Gluck | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Oct 2015 | 5,000 | 5,000 | - | - | Common Stock | |
| Timothy M. Shannon | None | 14 Oct 2015 | 3,566,337 | 0 | - | - | Series B-1 Convertible Preferred Stock |